Persistent pneumococcal colonisation: Dynamics, genomic diversity and evolution

Darwin College Sciences Group
Dr Chrispin Chaguza (Wellcome Sanger Institute, Cambridge)
The Richard King Room, Darwin College
Thursday, May 16, 2019 - 14:10 to 15:00

Bacterial evolution is a never-ending process and such innovation can lead to adaptation to clinical interventions such as antibiotics and vaccines thereby making them less effective. Streptococcus pneumoniae (the pneumococcus) is a human-adapted opportunistic pathogen once assigned the moniker “Captain of the men of death” by Sir William Osler because of its high death toll globally. Despite significant reduction of the invasive pneumococcal diseases (IPD) over the last two decades due to the introduction of effective higher-valent pneumococcal vaccines (PCVs), IPDs continue to kill hundreds of thousands of people globally. In this talk, I will describe colonisation dynamics, genomic diversity and evolution of the pneumococcus during persistent colonisation episodes in infants from a low-income and tropical Sub Saharan African setting with high carriage and disease burden during the first year of life.

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